Recombinant Human Neurotrophin 3(Human NT-3) _ C230458

Description

Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The NT-3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT-3. The amino acid sequence of mature NT-3 is identical in human, mouse and rat. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins.

 

Product Properties

 

Synonyms

HDNF ; NGF-2 ; NGF2 ; NT-3; NT3

Accession
P20783-1

Source

E. coli-derived human NT-3 protein, Tyr139-Thr257
Molecular Weight
Approximately 13.8 kDa.
AA Sequence
YA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL SRKIGRT
Tag
None
Purity
> 90% by SDS-PAGE.
concentration
0.46 mg/mL
Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized human NT3 at 2 μg/mL (100 μL/well)
can bind human TrkB-Fch. The EC50 of human TrkB-Fch is 120-350 ng/mL.
Endotoxin
< 1.0 EU per 1μg of the protein by the LAL method.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 5.2.

 

Storage

 

The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

 

Caution

 

1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only!

Recombinant Human Neurotrophin 3(Human NT-3) _ C230458

Product form

SKU: C230458E

$368.00

      • Tell a unique detail about this product

      Description

      Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The NT-3 cDNA encodes a 257 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature NT-3. The amino acid sequence of mature NT-3 is identical in human, mouse and rat. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins.

       

      Product Properties

       

      Synonyms

      HDNF ; NGF-2 ; NGF2 ; NT-3; NT3

      Accession
      P20783-1

      Source

      E. coli-derived human NT-3 protein, Tyr139-Thr257
      Molecular Weight
      Approximately 13.8 kDa.
      AA Sequence
      YA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL SRKIGRT
      Tag
      None
      Purity
      > 90% by SDS-PAGE.
      concentration
      0.46 mg/mL
      Biological Activity
      Measured by its binding ability in a functional ELISA. Immobilized human NT3 at 2 μg/mL (100 μL/well)
      can bind human TrkB-Fch. The EC50 of human TrkB-Fch is 120-350 ng/mL.
      Endotoxin
      < 1.0 EU per 1μg of the protein by the LAL method.
      Formulation
      Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 5.2.

       

      Storage

       

      The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

       

      Caution

       

      1. Avoid repeated freeze-thaw cycles.
      2. For your safety and health, please wear lab coats and disposable gloves for operation.
      3. For research use only!

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