Why Us
Integrated Production Process ensures the Quality of CleanRNA™ mRNA (Low dsRNA)
- Based on T7 RNA Polymerase (Low dsRNA)
- High purity
- Compresive Quality Control Ability
- ISO13485 Certified Facility
Top-notch mRNAs characterized by low dsRNA levels and exceptional integrity are indispensable for disease research utilizing mRNA tools and the advancement of RNA therapeutics.
Presently, mRNA synthesis offers numerous advantages, including mitigated risks of insertional mutagenesis, simplified cell-free manufacturing, and consistent performance irrespective of the cell cycle.
Our exclusive mRNA manufacturing process relies on T7 RNA Polymerase, enabling the production of high-quality mRNAs with remarkably low dsRNA content (approximately 1/100000), coupled with numerous customizable features.
Arcegen's mRNA production service simplifies your process from protein sequence to LNP delivery. Our expert team guarantees the excellence and expression effectiveness of your mRNA, offering a seamless, all-in-one solution.
RUO-grade mRNA usually does not control dsRNA content. However, preclinical mRNA typically requires dsRNA control and has higher demands for integrity. Our service can provide mRNA with extremely low dsRNA content, reaching the level of clinical mRNA
We can provide cGMP mRNA through our cooperative company.
Mostly, we use HPLC based purification for improving RNA purity in D-level room.
85% - 95% (≈2000nts);About 75%(≈9000nts)
The dsRNA content of CleanRNA™ mRNA is about 0.02 ng/μg, while that of conventional mRNA is about 1 ng/μg.
100bp to 20kb in length.
For RNA oligos shorter than 100bp, we offer chemical syntehsis.
1 mg/mL by default.
RNase-Free water is our default option. Please contact us for your specific requirement.
Yields by absorption at UV260 nm. Integrity by capillary electrophoresis
Yes.
Cap1 with capping efficiency >90%
Yes, we use enzyme digestion /LC-MS method.
100 nts
Yes, we do.
Yes.
We only accept plasmids synthesized by Arcegen.