Description
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup, where BMP2-7 belong to the TGF-β superfamily. It plays a leading role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. Mature human BMP-2 has 100% amino acid sequence identity with mouse and rat BMP-2. It shares 85% sequence identity with human BMP-4 and less than 51% sequence identity with other BMPs. Normal bone formation is a carefully regulated long-term process involving the continuous expression of growth regulatory factors by osteoblasts during proliferation and eventual differentiation. This orderly sequence of osteoblast gene expression indicates a cascade effect, which BMP-2 can initiate and maintain. BMP-2 also promotes the maintenance and repair of colonic epithelium, inhibits the synthesis and release of neuronal dopamine, induces apoptosis in medulloblastoma cells, and is necessary for myocardial contractility.
Product Properties
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Synonyms
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BDA2, BMP2, BMP-2, BMP-2A, SSFSC
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Source
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E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met
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Endotoxin
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< 0.1 EU per μg by the LAL method.
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Purity
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> 95% by SDS-PAGE and HPLC analyses.
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Formulation
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Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM sodium citrate, pH 3.5.
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Applications
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ELISA, Kinetics (BLI), Kinetics (SPR), Immunization
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Dilution
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Dilute in sterile distilled water.
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Storage
The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
