Recombinant Human/Mouse/Rat BMP-2 Protein_C230308

Description

Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup, where BMP2-7 belong to the TGF-β superfamily. It plays a leading role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. Mature human BMP-2 has 100% amino acid sequence identity with mouse and rat BMP-2. It shares 85% sequence identity with human BMP-4 and less than 51% sequence identity with other BMPs. Normal bone formation is a carefully regulated long-term process involving the continuous expression of growth regulatory factors by osteoblasts during proliferation and eventual differentiation. This orderly sequence of osteoblast gene expression indicates a cascade effect, which BMP-2 can initiate and maintain. BMP-2 also promotes the maintenance and repair of colonic epithelium, inhibits the synthesis and release of neuronal dopamine, induces apoptosis in medulloblastoma cells, and is necessary for myocardial contractility.

 

Product Properties

 

Synonyms

BDA2, BMP2, BMP-2, BMP-2A, SSFSC

Source

E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met

Endotoxin

< 0.1 EU per μg by the LAL method.

Purity

> 95% by SDS-PAGE  and HPLC analyses.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM sodium citrate, pH 3.5.

Applications

ELISA, Kinetics (BLI), Kinetics (SPR), Immunization

Dilution

Dilute in sterile distilled water.

 

Storage

 

 The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

 

Cautions

 

1. Please operate with lab coats and disposable gloves,for your safety.       

2. This product is for research use only.  

Recombinant Human/Mouse/Rat BMP-2 Protein_C230308

Product form

SKU: C230308E

$179.00

    • Shipped today? Order within: Jul 17, 2024 17:00:00 -0400
    • Tell a unique detail about this product

    Description

    Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup, where BMP2-7 belong to the TGF-β superfamily. It plays a leading role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. Mature human BMP-2 has 100% amino acid sequence identity with mouse and rat BMP-2. It shares 85% sequence identity with human BMP-4 and less than 51% sequence identity with other BMPs. Normal bone formation is a carefully regulated long-term process involving the continuous expression of growth regulatory factors by osteoblasts during proliferation and eventual differentiation. This orderly sequence of osteoblast gene expression indicates a cascade effect, which BMP-2 can initiate and maintain. BMP-2 also promotes the maintenance and repair of colonic epithelium, inhibits the synthesis and release of neuronal dopamine, induces apoptosis in medulloblastoma cells, and is necessary for myocardial contractility.

     

    Product Properties

     

    Synonyms

    BDA2, BMP2, BMP-2, BMP-2A, SSFSC

    Source

    E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met

    Endotoxin

    < 0.1 EU per μg by the LAL method.

    Purity

    > 95% by SDS-PAGE  and HPLC analyses.

    Formulation

    Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM sodium citrate, pH 3.5.

    Applications

    ELISA, Kinetics (BLI), Kinetics (SPR), Immunization

    Dilution

    Dilute in sterile distilled water.

     

    Storage

     

     The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

    Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

     

    Cautions

     

    1. Please operate with lab coats and disposable gloves,for your safety.       

    2. This product is for research use only.  

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