Description
Description
Interleukin 5 (IL-5) is a member of the hematopoietic Th2 cytokine family and consists of 115 amino acids. Unlike other members of the cytokine family (IL-3 and GM-CSF), this glycoprotein is activated as a homologous dimer. IL-5 is secreted by Th2 cells and mast cells. Its biological activity on B cells and other cell types suggests that IL-5 is functionally important for Th2 cell activity. By binding to its receptor, IL-5 stimulates B cell growth and enhances immunoglobulin secretion. It is also a key factor in the activation of eosinophils. IL-5 has been associated with a variety of diseases, including allergic rhinitis and asthma, with substantial increases seen in circulating tissue, tracheal tissue, and a decrease in sputum eosinophils.
Product Properties
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Synonyms
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TRF,Interleukin-5
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Uniprot No.
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P05113-1
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Source
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Recombinant Human IL-5 Protein is expressed from HEK293 Cells with His tag at the N-terminal and Fc tag at the C-terminal. It contains Ile20-Ser134.
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Molecular Weight
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The protein has a predicted MW of 45.33 kDa.
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Purity
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> 95% as determined by SDS-PAGE.
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Endotoxin
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<0.1 EU per 1μg of the protein by the LAL method.
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Formulation
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Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
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Reconstitution
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Centrifuge tubes before opening. The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 ug/mL.
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Shipping and Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt. 2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Cautions
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
