Recombinant Human Hepatocyte Growth Factor (Human HGF)_C230260

Description

HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF
include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE‑like domain, four Kringle domains, and a serine proteinase-like
domain that has no detectable protease activity.

Product Properties

Synonyms

Scatter Factor (SF), Hepatopoietin (HPTA)
Accession
P14210
Gene ID
3082
Source
CHO-derived Human HGF protein, Gln32-Ser728
Molecular Weight
88~90 kDa (single chain), 59~61 kDa (alpha chain), 30~34 kDa (beta chain), on SDS-PAGE under reducing conditions.
Tag
None
Purity
> 95% by SDS-PAGE
Biological Activity
ED50 < 10.0 ng/ml, measured in a cell proliferation assay using 4MBr5 cells, corresponding to a specific activity of > 1.0 × 10 5 units/mg.
Endotoxin
< 0.2 EU per 1μg of the protein by the LAL method.
Formulation
Lyophilized after extensive dialysis against PBS
Reconstitution
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added.


Shipping and Storage
The products are shipped with ice pack and can be stored at -80℃ for 1 year.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 °C under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

Cautions
1. Avoid repeated freeze-thaw cycles.
2. For your safety and health, please wear lab coats and disposable gloves for operation.
3. For research use only.

Recombinant Human Hepatocyte Growth Factor (Human HGF)_C230260

Product form

SKU: C230260E

$258.00

      • Tell a unique detail about this product

      Description

      HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF
      include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE‑like domain, four Kringle domains, and a serine proteinase-like
      domain that has no detectable protease activity.

      Product Properties

      Synonyms

      Scatter Factor (SF), Hepatopoietin (HPTA)
      Accession
      P14210
      Gene ID
      3082
      Source
      CHO-derived Human HGF protein, Gln32-Ser728
      Molecular Weight
      88~90 kDa (single chain), 59~61 kDa (alpha chain), 30~34 kDa (beta chain), on SDS-PAGE under reducing conditions.
      Tag
      None
      Purity
      > 95% by SDS-PAGE
      Biological Activity
      ED50 < 10.0 ng/ml, measured in a cell proliferation assay using 4MBr5 cells, corresponding to a specific activity of > 1.0 × 10 5 units/mg.
      Endotoxin
      < 0.2 EU per 1μg of the protein by the LAL method.
      Formulation
      Lyophilized after extensive dialysis against PBS
      Reconstitution
      It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added.


      Shipping and Storage
      The products are shipped with ice pack and can be stored at -80℃ for 1 year.
      1 week, 2 to 8 °C under sterile conditions after reconstitution.
      3 months, -20 °C under sterile conditions after reconstitution.
      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

      Cautions
      1. Avoid repeated freeze-thaw cycles.
      2. For your safety and health, please wear lab coats and disposable gloves for operation.
      3. For research use only.

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