Streptozocin_C331605

Description

Product description

Streptozocin (STZ) is an antibiotic produced by Streptomyces Aureobasidium pullulans. It has anti-tumor effects and is often used to treat pancreatic cancer. At the same time, STZ can selectively destroy pancreatic beta cells in certain species of animals and induce diabetes. It can be used for modeling research on diabetes models. Rats and mice are generally used to create animal models.

The preparation of type Ⅰ diabetes and type Ⅱ diabetes animal models is related to the dose of STZ injection: when a high dose is injected, it can directly cause extensive destruction of pancreatic islet β cells, which can cause a type Ⅰ diabetes model; when a smaller amount of STZ is injected, it only destroys the function of a part of the pancreatic islet β cells, causing peripheral tissues to be insensitive to insulin. At the same time, high-calorie feed is given. The combination of the two can induce an animal model with pathological and physiological changes close to human type Ⅱ diabetes. Generally speaking, high doses of STZ can induce type I diabetes models, while low doses of STZ plus high-fat and high-sugar feed can induce type II diabetes models.

In addition, STZ has also been widely studied in anti-leukemia, DNA methylation, anti-nephritis and other aspects.


Specifications

English Synonym

Streptozotocin

CAS NO.

18883-66-4

Formula

C8H15N3O7

Molecular Weight

265.22

Appearance

White or light yellow powder

Purity

≥98%

Solubility

Soluble in water, lower alcohols, ketones, etc.

Structure


Components

Components No.

C331605E

C331605S

C331605M

Size

100 mg

500 mg

1 g


Storage

Ice pack shipping. -15℃ ~-25℃ storage, away from moisture and light, valid for 2 years.

Documents:

Streptozocin_C331605

Product form

SKU: C331605E

$65.00

    • Tell a unique detail about this product

    Description

    Product description

    Streptozocin (STZ) is an antibiotic produced by Streptomyces Aureobasidium pullulans. It has anti-tumor effects and is often used to treat pancreatic cancer. At the same time, STZ can selectively destroy pancreatic beta cells in certain species of animals and induce diabetes. It can be used for modeling research on diabetes models. Rats and mice are generally used to create animal models.

    The preparation of type Ⅰ diabetes and type Ⅱ diabetes animal models is related to the dose of STZ injection: when a high dose is injected, it can directly cause extensive destruction of pancreatic islet β cells, which can cause a type Ⅰ diabetes model; when a smaller amount of STZ is injected, it only destroys the function of a part of the pancreatic islet β cells, causing peripheral tissues to be insensitive to insulin. At the same time, high-calorie feed is given. The combination of the two can induce an animal model with pathological and physiological changes close to human type Ⅱ diabetes. Generally speaking, high doses of STZ can induce type I diabetes models, while low doses of STZ plus high-fat and high-sugar feed can induce type II diabetes models.

    In addition, STZ has also been widely studied in anti-leukemia, DNA methylation, anti-nephritis and other aspects.


    Specifications

    English Synonym

    Streptozotocin

    CAS NO.

    18883-66-4

    Formula

    C8H15N3O7

    Molecular Weight

    265.22

    Appearance

    White or light yellow powder

    Purity

    ≥98%

    Solubility

    Soluble in water, lower alcohols, ketones, etc.

    Structure


    Components

    Components No.

    C331605E

    C331605S

    C331605M

    Size

    100 mg

    500 mg

    1 g


    Storage

    Ice pack shipping. -15℃ ~-25℃ storage, away from moisture and light, valid for 2 years.

    Documents:

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