Dextran Sulfate Sodium Salt, MW36000~50000_C331601

Description

Product description

Dextran sulfate sodium(DSS) is a polyanionic derivative of dextran, formed by the esterification reaction of dextran and chlorosulfonic acid. It is commonly used in colitis modeling research. DSS has several characteristics:1) It is a polyanionic compound soluble in water, forming a colorless aqueous solution; 2) It exhibits high purity and good stability; 3) It is naturally degradable.

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including ulcerative colitis (UC) and Crohn’s disease (CD). Since its first reported use in 1985 for inducing ulcerative colitis-like symptoms in mice, using dextran sulfate sodium (DSS), numerous studies have confirmed the similarity of the DSS colitis model to human ulcerative colitis.The histological features, clinical manifestations, the disease site and cytokine proliferation of DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, cost-effective, reproducible, easy to master, and can be easily adapted and standardized. Depending on the experimental objectives, the DSS concentration and administration timing can be adjusted to establish acute, chronic, or alternate acute-chronic models.

Specifications

English Synonym

Dextran Sulfate Sodium Salt, DSS; Dextran Sodium sulfate

CAS NO.

9011-18-1

Formula

(C6H7Na3O14S3) n

Molecular Weight

36, 000 ~50, 000 Da

Appearance

White or off-white powder

Solubility

Soluble in water, slightly soluble in ethanol.


Components

Components No.

C331601E

C331601S

C331601M

C331601L

Size

25 g

100 g

500 g

1 kg


Storage

The product is shipped and stored at room temperature, valid for 2 years.

Documents:

Dextran Sulfate Sodium Salt, MW36000~50000_C331601

Product form

SKU: C331601E

$435.00

    • Tell a unique detail about this product

    Description

    Product description

    Dextran sulfate sodium(DSS) is a polyanionic derivative of dextran, formed by the esterification reaction of dextran and chlorosulfonic acid. It is commonly used in colitis modeling research. DSS has several characteristics:1) It is a polyanionic compound soluble in water, forming a colorless aqueous solution; 2) It exhibits high purity and good stability; 3) It is naturally degradable.

    Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including ulcerative colitis (UC) and Crohn’s disease (CD). Since its first reported use in 1985 for inducing ulcerative colitis-like symptoms in mice, using dextran sulfate sodium (DSS), numerous studies have confirmed the similarity of the DSS colitis model to human ulcerative colitis.The histological features, clinical manifestations, the disease site and cytokine proliferation of DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, cost-effective, reproducible, easy to master, and can be easily adapted and standardized. Depending on the experimental objectives, the DSS concentration and administration timing can be adjusted to establish acute, chronic, or alternate acute-chronic models.

    Specifications

    English Synonym

    Dextran Sulfate Sodium Salt, DSS; Dextran Sodium sulfate

    CAS NO.

    9011-18-1

    Formula

    (C6H7Na3O14S3) n

    Molecular Weight

    36, 000 ~50, 000 Da

    Appearance

    White or off-white powder

    Solubility

    Soluble in water, slightly soluble in ethanol.


    Components

    Components No.

    C331601E

    C331601S

    C331601M

    C331601L

    Size

    25 g

    100 g

    500 g

    1 kg


    Storage

    The product is shipped and stored at room temperature, valid for 2 years.

    Documents:

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