Description
Product description
Dextran sulfate sodium(DSS) is a polyanionic derivative of dextran, formed by the esterification reaction of dextran and chlorosulfonic acid. It is commonly used in colitis modeling research. DSS has several characteristics:1) It is a polyanionic compound soluble in water, forming a colorless aqueous solution; 2) It exhibits high purity and good stability; 3) It is naturally degradable.
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including ulcerative colitis (UC) and Crohn’s disease (CD). Since its first reported use in 1985 for inducing ulcerative colitis-like symptoms in mice, using dextran sulfate sodium (DSS), numerous studies have confirmed the similarity of the DSS colitis model to human ulcerative colitis.The histological features, clinical manifestations, the disease site and cytokine proliferation of DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, cost-effective, reproducible, easy to master, and can be easily adapted and standardized. Depending on the experimental objectives, the DSS concentration and administration timing can be adjusted to establish acute, chronic, or alternate acute-chronic models.
Specifications
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English Synonym
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Dextran Sulfate Sodium Salt, DSS; Dextran Sodium sulfate
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CAS NO.
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9011-18-1
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Formula
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(C6H7Na3O14S3) n
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Molecular Weight
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36, 000 ~50, 000 Da
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Appearance
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White or off-white powder
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Solubility
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Soluble in water, slightly soluble in ethanol.
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Components
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Components No.
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C331601E
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C331601S
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C331601M
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C331601L
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Size
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25 g
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100 g
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500 g
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1 kg
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Storage
The product is shipped and stored at room temperature, valid for 2 years.
