Recombinant Rhesus Macaque Interleukin-3 (Rhesus Macaque IL-3)_ C230725

Description

Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation. At the amino acid sequence level, mature human and murine IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on murine cells. Cytokines are actively involved in the host-defense system to coordinate the functional activity and the generation of effector cells. Some of these molecules function as inflammatory mediators and hematopoietic growth factors at the same time such as IL-3. IL-3 (or multi-CSF) is known as a pleiotropic cytokine with a broad spectrum of target cells and functions. IL-3 regulates the proliferation and differentiation of normal hematopoietic progenitor cells in the early stages of hematopoiesis. And IL-3 inhibits apoptosis and promotes the autonomous growth of blast cells.

Product Properties

 

Synonyms

Hematopoietic Growth Factor, MCGF, Multipotential Colony-stimulating Factor, P-cell-stimulating
Factor

Source

E.coli-derived Rhesus Macaque IL-3, Ala20-Gln143.

AA sequence

APMTQTTSLK TSWAKCSNMI DEIITHLNQP PLPSPDFNNL NEEDQTILVE KNLRRSNLEA 
FSKAVKSLQN ASAIESILKN LPPCLPMATAAPTRPPIRIT NGDRNDFRRK LKFYLKTLEN EQAQ

Endotoxin

< 1.0 EU per μg by the LAL method.

Purity

> 98% by SDS-PAGE and HPLC analyses.

Formulation

Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4, 5 % trehalose.

Applications

ELISA, Kinetics (BLI), Kinetics (SPR), Immunization

Dilution

Dilute with sterile distilled water or aqueous buffer containing 0.1% BSA.

 

Storage

 

The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

 

Cautions

 

1. Please operate with lab coats and disposable gloves,for your safety.       

2. This product is for research use only.  

Recombinant Rhesus Macaque Interleukin-3 (Rhesus Macaque IL-3)_ C230725

Product form

SKU: C230725E

$155.00

      • Tell a unique detail about this product

      Description

      Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation. At the amino acid sequence level, mature human and murine IL-3 share only 29% sequence identity. Consistent with this lack of homology, IL-3 activity is highly species-specific and human IL-3 does not show activity on murine cells. Cytokines are actively involved in the host-defense system to coordinate the functional activity and the generation of effector cells. Some of these molecules function as inflammatory mediators and hematopoietic growth factors at the same time such as IL-3. IL-3 (or multi-CSF) is known as a pleiotropic cytokine with a broad spectrum of target cells and functions. IL-3 regulates the proliferation and differentiation of normal hematopoietic progenitor cells in the early stages of hematopoiesis. And IL-3 inhibits apoptosis and promotes the autonomous growth of blast cells.

      Product Properties

       

      Synonyms

      Hematopoietic Growth Factor, MCGF, Multipotential Colony-stimulating Factor, P-cell-stimulating
      Factor

      Source

      E.coli-derived Rhesus Macaque IL-3, Ala20-Gln143.

      AA sequence

      APMTQTTSLK TSWAKCSNMI DEIITHLNQP PLPSPDFNNL NEEDQTILVE KNLRRSNLEA 
      FSKAVKSLQN ASAIESILKN LPPCLPMATAAPTRPPIRIT NGDRNDFRRK LKFYLKTLEN EQAQ

      Endotoxin

      < 1.0 EU per μg by the LAL method.

      Purity

      > 98% by SDS-PAGE and HPLC analyses.

      Formulation

      Lyophilized from a 0.2 µm filtered concentrated solution in PBS, pH 7.4, 5 % trehalose.

      Applications

      ELISA, Kinetics (BLI), Kinetics (SPR), Immunization

      Dilution

      Dilute with sterile distilled water or aqueous buffer containing 0.1% BSA.

       

      Storage

       

      The products are shipped with ice pack and can be stored at -20℃ to -80℃ for 1 year.

      Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.

       

      Cautions

       

      1. Please operate with lab coats and disposable gloves,for your safety.       

      2. This product is for research use only.  

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